Tag Archives: histamine and MTHFR

Basic summary on MTFHR mutation detrimental health effects

Multiple studies have been conducted on the subject of MTFHR mutations and their impact on how our body work on a daily basis. MTHFR’s function in our body is to perform a process called methylation inside our cells. By doing so, MTHFR can help create, convert, and alter compounds within our cells. Methylation impacts many processes. It is involved in cellular repair and the production of DNA. It helps with neurotransmitter production and it is also vital in the formation and development of red blood cells, white blood cells, platelets, and the maintenance of a healthy immune system.

Research studies including “Assocation between MTHFR C677T polymorphism and depression: an updated meta-analysis of 26 studies” and  “ Angiotensin converting enzyme and MTFHR gene variations in fibriomyalgia syndrome” have found that there is in fact a strong link between MTFHR variations and detrimental health conditions such as depression, chronic fatigue and fibromyalgia, among others. These studies have also shown that active forms of vitamin B12 and folinic acid are helpful in treating the negative effects of the mutation.

Today, over 60% of the world’s population has a vartiation on their MTHFR gene. Although some people never present negative side effects or health conditions due to this muation, an increasing number of people suffer consequences from the mutation. This in part is because epigenetic plays a huge role. Epigenetic is the non-genetic influence of gene expression.  Simply put, our diet, stress levels, environment, lifestyle can have an impact on how the gene is expressed. Screening for MTFHR mutation is highly recommended for all patients who suffer from chronic mental, neurological, pain conditions such as depression, anxiety, fibromyalgia, and ADHD, as well as histamine related conditions such as hives and itchy skin.

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